THE GUT-BRAIN AXIS IN CHILDHOOD NEURODIVERGENCE: IMPACT OF INTESTINAL DYSBIOSIS ON BEHAVIORAL MODULATION IN AUTISM SPECTRUM DISORDER(ASD)
DOI:
https://doi.org/10.63391/end84c51Keywords:
Gut-brain axis, ; intestinal dysbiosis, ; autism., ; microbiota, ; child behaviorAbstract
The gut-brain axis has gained prominence in research on Autism Spectrum Disorder (ASD), especially regarding the influence of the gut microbiota on children's behavior. This axis represents a bidirectional communication pathway between the central nervous system and the gastrointestinal system, mediated by neural, hormonal, and immunological mechanisms. In neurodivergent children, alterations in the composition of the microbiota—known as gut dysbiosis—have been associated with behavioral symptoms such as irritability, anxiety, difficulties in social interaction, and repetitive patterns. Dysbiosis can compromise the production of important neurotransmitters, such as serotonin, and increase inflammatory processes that directly impact brain function. Therefore, gut balance becomes a relevant factor in understanding and managing ASD. Interventions such as dietary changes, the use of probiotics, and multidisciplinary follow-up have shown potential in improving symptoms, although further studies are needed to consolidate this evidence. Understanding the gut-brain axis broadens the possibilities for comprehensive care, considering not only neurological aspects but also the biological and environmental factors that influence child development.
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References
Adams, J. B., Johansen, L. J., Powell, L. D., Quig, D., & Rubin, R. A. (2011).
Gastrointestinal flora and gastrointestinal status in children with autism. BMC Gastroenterology.
Cryan, J. F., O’Riordan, K. J., Cowan, C. S. M., et al. (2019).
The microbiota-gut-brain axis. Physiological Reviews.
Dinan, T. G., & Cryan, J. F. (2017).
The microbiome-gut-brain axis in health and disease. Gastroenterology Clinics.
Frye, R. E., Slattery, J., MacFabe, D. F., et al. (2015).
Approaches to studying and manipulating the enteric microbiome to improve autism symptoms. Microbial Ecology in Health and Disease.
Hsiao, E. Y., McBride, S. W., Hsien, S., et al. (2013).
Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell.
Kang, D. W., Adams, J. B., Gregory, A. C., et al. (2017).
Microbiota Transfer Therapy alters the gut ecosystem and improves gastrointestinal and autism symptoms. Microbiome.
Mayer, E. A. (2016).
The Mind-Gut Connection. New York: Harper Wave.
Rogers, G. B., Keating, D. J., Young, R. L., et al. (2016).
From gut dysbiosis to altered brain function and mental illness. Microbiome.
Sharon, G., Sampson, T. R., Geschwind, D. H., & Mazmanian, S. K. (2016).
The central nervous system and the gut microbiome. Cell.
Silva, Y. P., Bernardi, A., & Frozza, R. L. (2020).
The role of short-chain fatty acids from gut microbiota in gut-brain communication. Frontiers in Endocrinology.
Strati, F., Cavalieri, D., Albanese, D., et al. (2017).
New evidence on the altered gut microbiota in autism spectrum disorders. Microbiome.
Vuong, H. E., & Hsiao, E. Y. (2017).
Emerging roles for the gut microbiome in autism spectrum disorder. Biological Psychiatry.
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