EFFICACY OF FOLINIC ACID(LEUCOVORIN) IN AUTISM SPECTRUM DISORDER: MODULATION OF SYMPTOMS IN PATIENTS WITH FOLATE RECEPTOR ALPHA AUTOANTIBODIES

Abstract

This study explores, in a clear and accessible way, the effectiveness of folinic acid (leucovorin) in modulating symptoms in individuals with Autism Spectrum Disorder (ASD), particularly those who present autoantibodies against the folate receptor alpha. It is based on the understanding that disruptions in folate metabolism may directly affect neurological development and brain function, influencing language, behavior, and cognition. The presence of these autoantibodies can impair the transport of folate into the central nervous system, leading to significant functional deficits. In this context, folinic acid emerges as a therapeutic alternative due to its ability to bypass this blockage and improve folate availability in the brain. Recent studies suggest improvements in verbal communication, social interaction, and a reduction in repetitive behaviors in some treated patients. However, results are not uniform, highlighting the importance of individualized assessment and careful clinical monitoring. It is concluded that leucovorin may represent a promising strategy, particularly for specific subgroups within the spectrum, reinforcing the relevance of personalized approaches in ASD management.